Simulation-Supported Spray-Drying Development and Scale-Up for Amorphous Solid Dispersions

How can simulation support spray-drying development and scale-up?

Explore how physics-based simulation can support spray-drying process development for amorphous solid dispersions (ASDs). This white paper outlines how a practical modelling framework—covering atomisation, evaporation, heat transfer, and thermodynamics—can be used to predict key process indicators such as particle size, temperature, and solvent loading. By narrowing the experimental design space and enabling more targeted studies, simulation can help reduce trial-and-error and support more confident scale-up and technology transfer.

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Simulation-Supported Spray-Drying Development and Scale-Up for Amorphous Solid Dispersions