Microencapsulation
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Advanced Microencapsulation Technology
Codis’ microencapsulation technology utilizes a scalable, industry-proven spinning disc process to embed a variety of ingredients, such as vitamins, minerals, and pharmaceutical APIs, within a hydrophobic vegetable fatty acid matrix. This lipid barrier shields the active from direct contact with taste buds and olfactory receptors, delivering effective taste and odor masking. The encapsulation also protects sensitive actives from environmental degradation, enhancing stability and shelf life. In addition, the coating can enable controlled or delayed release, allowing for targeted delivery and optimal performance across a wide range of oral dosage forms.
The Codis Microencapsulation Advantage
Our proprietary microencapsulation process delivers performance and flexibility unmatched by conventional techniques:
Solvent-free processing
ensures an environmentally friendly, pure product with no residual solvents
Robust, uniform coatings
protect particles during downstream processing without rupturing
Exceptional taste and odor masking
enhances the palatability of nutritional and pharmaceutical ingredients
Improved stability
safeguards sensitive actives from environmental degradation
Free-flowing, directly compressible granules
improve tableting efficiency and throughput
Excellent mouthfeel and dissolution
for optimal patient and consumer experience
Controlled- or delayed-release
options support diverse delivery profiles
Flavor-infused coatings
enable creative product development
How Does Codis Microencapsulation Work?
Discover the process of creating and benefits of microencapsulation for enhanced compound performance
Our process starts by suspending the material to be encapsulated in a molten fatty acid or glyceride. The suspension is then fed to a rapidly rotating disc that breaks the bulk liquid stream into fine, uniform droplets via centrifugal force. The droplets are contacted with cooling gas that quickly solidifies the lipid matrix, embedding the active ingredients within the particle. The resulting barrier limits direct contact between the active and taste or odor receptors, protects sensitive ingredients from environmental exposure, and can be engineered to modify when the active is released. Because the process is solvent-free, the finished material contains no residual process solvent.
When Is Microencapsulation Used?
Microencapsulation Applications
Our microencapsulation technology enables taste masking, odor control, stability enhancement, and tailored release profiles across a wide range of nutritional, OTC, and prescription applications.
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Nutritional
Transform the sensory experience of fortified products while enhancing stability and performance. Nutritional applications for our microencapsulation technology include:
- Chewable multivitamin and mineral tablets
- Nutrient-fortified powdered beverage mixes
- Energy and nutrition bars
- Fortified pre-mix blends
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Prescription (Rx) & OTC
Deliver better-tasting, patient-friendly medicines that maintain potency and meet rigorous quality standards. Applications include:
- Pediatric and adult chewable tablets
- Pediatric and adult orally dissolving tablets (ODTs)
- Pediatric and adult flavored orally dissolving powders (ODPs)
Codis Microencapsulation At-a-Glance
Facility Highlights
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Manufacturing Facility:
St Louis, Missouri, USA
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Compliance:
The facility and its processes comply with US FDA 21 CFR Parts 210/211, 110/111, and 117, as well as EU drug certification standards.
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Standard Products:
Our full line of Descote® vitamins and minerals ; MicroMask® APIs
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Custom Products:
We develop and manufacture customized, proprietary client compounds in the vitamin, mineral, OTC, and pharmaceutical markets. Contact us to get started.
Frequently Asked Questions About Microencapsulation
Explore popular questions and topics on our microencapsulation services
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Microencapsulation surrounds or embeds an active ingredient within a protective material. The barrier can mask taste or odor, improve stability and handling, protect the active during downstream processing, or modify its release profile.
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Yes, Codis uses a proprietary solvent-free spinning disc process based on a hydrophobic vegetable fatty acid or glyceride matrix, eliminating residual process solvents.
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Published applications include chewable tablets, orally dissolving tablets, orally dissolving powders, powdered beverage mixes, nutrition bars, and premix blends.
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Yes, Codis offers Descote® vitamins and minerals and MicroMask® APIs, as well as customized proprietary compounds for vitamin, mineral, OTC, and pharmaceutical markets.
Discover Codis
Explore how Codis applies its expertise in spray drying, microencapsulation, continuous granulation, final dosage forms, and functional products to meet your formulation and manufacturing needs.
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Commercial Spray Drying
Full lifecycle, development, and production expertise for high-volume commercial aqueous spray drying.
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Codis Amorphous Solid Dispersion (ASD)
Industry-leading know-how to design, scale, and manufacture amorphous solid dispersions for improved bioavailability of poorly soluble compounds.
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Microencapsulation
Proprietary microencapsulation processes to improve taste, odor masking, stability, or release profile.
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Continuous Granulation
Continuous high-shear granulation to improve flow, compressibility and disintegration.
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Organic & Polymer Chemistry
Advanced organic synthesis and polymer engineering, enabling robust, scalable manufacturing.
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Analytical Services
State-of-the-art instrumentation combined with data-science–driven PAT to provide method development, validation, release, and stability testing services.
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Final Dosage Forms
Leading global experts in direct compression and two-piece encapsulation products for vitamin, mineral and supplement markets.
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