Solvent-Based Spray Drying and Amorphous Solid Dispersions (ASD)
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Amorphous Solid Dispersions Core Capabilities
Delivering Critical ASD Product Properties
Codis enables oral bioavailability of DCS Class 2a, 2b, and 4 compounds through spray drying of amorphous solid dispersions. Our solvent-capable spray dryers operate in closed-loop mode under inert nitrogen gas and feature twin-fluid and high-pressure atomization capabilities, enabling us to target critical ASD product properties, such as particle size, flow characteristics, and compaction attributes. Our equipment is compatible with volatile process solvents, including acetone, methanol, ethanol, dichloromethane, and mixtures thereof.
ASD Formulation & Process
Possibilities include a variety of compendial material grades that cover neutral, enteric, and anti-enteric modalities.
Povidone & Derivatives
Hypromellose & Derivatives
Eudragit®
With your ASD composition defined, Codis covers your cGMP clinical and commercial ASD manufacturing requirements using two spray dryer equipment scales.
Our PROCEPT SD1 handles batch sizes from grams up to 2kg, making it a suitable platform for early process development as well as preclinical and early-phase clinical supplies. Our larger GEA NIRO® PSD-2 handles batch sizes ranging from 10 kg to 100 kg, making it suitable for process scale-up, late-phase clinical supply, and small-scale commercial ASD production. Feed vessels with capacities of up to 4000L are available. Both platforms are equipped with containment technologies suitable for the safe handling of high-potency APIs (HPAPIs), with OEB4 levels of 1-10 µg/m³. Solvent levels are reduced to within ICH limits using vacuum dryers at small scale and EKATO SOLIDMIX vertical vacuum dryer technology for larger batch sizes.
Additional Spray Dried Product Types
Codis has the depth of experience and expertise to support your specialty products requiring aqueous or solvent-based spray drying. Whether powder for inhalation, nasal delivery, API isolation, or functional excipients, we’re here to help turn your ideas into quality products. Contact us to learn more about how we can apply our capabilities to manufacture your spray dried products.
Discover Codis
Explore how Codis applies its expertise in spray drying, microencapsulation, continuous granulation, final dosage forms, and functional products to meet your formulation and manufacturing needs.
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Commercial Spray Drying
Full lifecycle, development, and production expertise for high-volume commercial aqueous spray drying.
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Codis Amorphous Solid Dispersion (ASD)
Industry-leading know-how to design, scale, and manufacture amorphous solid dispersions for improved bioavailability of poorly soluble compounds.
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Microencapsulation
Proprietary microencapsulation processes to improve taste, odor masking, stability, or release profile.
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Continuous Granulation
Continuous high-shear granulation to improve flow, compressibility and disintegration.
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Organic & Polymer Chemistry
Advanced organic synthesis and polymer engineering, enabling robust, scalable manufacturing.
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Analytical Services
State-of-the-art instrumentation combined with data-science–driven PAT to provide method development, validation, release, and stability testing services.
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Final Dosage Forms
Leading global experts in direct compression and two-piece encapsulation products for vitamin, mineral and supplement markets.
Codis Insights & Updates
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