Simulation-Supported Spray-Drying Development and Scale-Up for Amorphous Solid Dispersions

This technical white paper outlines a practical, simulation-led approach to spray-drying development and scale-up for amorphous solid dispersions (ASDs). It explores how process modelling can support more informed decision-making, from defining operating windows to guiding technology transfer across scales. By integrating atomisation, evaporation, and heat transfer principles, the paper demonstrates how simulation can reduce experimental burden, improve process understanding, and enable more efficient development of robust spray-drying processes.

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Simulation-Supported Spray-Drying Development and Scale-Up for Amorphous Solid Dispersions